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accueil (home) crnl revues lectroniques site sommeil ralisation team leader : jian sheng lin - +33 (0)0478777116 equipe physiologie intégrée du système d'éveil, faculté de médecine, université claude bernard lyon 1, 8 avenue rockefeller, 69373 lyon cedex 08, france phone : +33 (0)478777041 - fax : +33 (0)478777150 email : u628@univ-lyon1.fr http://icoprem.univ-lyon1.fr/4-laboratoire41-crnl-physiologie-integree-du-systeme-d_eveil-ex-u628.html http://sommeil.univ-lyon1.fr http://crnl.univ-lyon1.fr/index.php/fr our goal is to unravel the mechanisms of wake and associated pathologies: narcolepsy, excessive daytime sleepiness, insomnia, metabolic disorders, sudden infant death syndrome. from a basic research standpoint, we dissect the mechanisms of wake through the study of the specific, complementary and synergistic roles of histaminergic and orexinergic neurons in particular. using specific knock out mice and detailed behavioral and electroencephalographic measures, we will determine how the two systems interact synergistically and integrate into the central mechanisms of sleep-wake alteration (js lin, k sakai). we also use intracellular recordings, local field potentials and biosensors to study the properties of the cortical network during different types of behavioral states, the respective role of diffuse ascending systems and specific cerebral nuclei, and the mechanisms and effects of extra-synaptic variations of neurotransmitter (s. crochet, s marinesco). from a physio-pathological and translational research standpoint, we work on 1) developing therapeutic approaches for narcolepsy and excessive daytime sleepiness using our knowledge of histaminergic and orexinergic systems (p franco, js lin), 2) investigating the interactions between sleep loss and metabolic disorders in lean subjects and obese patients and in animal models combining sleep/wake and metabolic alterations (k. spiegel), and 3) identifying new signaling pathways and biomarkers associated with wake thanks to drosophila molecular genetics (l. seugnet). our work is thus characterized by the use multidisciplinary methodological approaches: electrophysiology and behavior, biosensors, clinical investigations, molecular genetics, and the development of tools for both diagnostic and therapy. please click on individual names in the list below for more information. methodology electrophysiology (eeg, local field potential, intra and extracellular recordings in behavioral mice and cats) polysomnography in animals (mouse, cat) and humans (adult,child) biosensors (electrochemistry) immunohistochemistry neuro-behavioural testing neuropharmacology cognitive, metabolic and endocrine testing in humans animal models for sleep disorders (mouse, cat) sleep molecular genetics in drosophila keywords : waking, arousal, sleep, slow wave sleep, rem sleep, cortical activation, posterior hypothalamus, histamine, orexin, sleep-wake disorder, somnolence, waking substance, mesopontine tegmentum, neurophysiology, cat, mouse brief history of the laboratory scientific presentation of the laboratory (pdf) list of publication prsentation scientifique grand public (franais) bref historique du laboratoire (franais) group pictures les 29 membres # name position org. teams pubmed 1 lin jian sheng dr1 inserm crnl waking team (team leader) crnl waking team » crnl waking team (team leader) 2 perrot franoise sarcn inserm crnl waking team (secretary) # name position org. teams pubmed 1 achaintre laetitia inserm crnl waking team » crnl waking team 2 akaoka hideo cr1 cnrs crnl waking team » crnl waking team 3 anaclet christelle inserm crnl waking team » crnl waking team 4 buda colette ie inserm crnl waking team » crnl waking team 5 cespuglio raymond dr1 + hdr inserm crnl waking team » crnl waking team 6 challamel marie josephe cr1 inserm crnl waking team » crnl waking team 7 crochet sylvain cr1 inserm crnl waking team » crnl waking team 8 fernandez laura these inserm crnl waking team » crnl waking team 9 franco patricia mcuph hosp-univ crnl waking team » crnl waking team 10 gentet luc cr1 inserm crnl waking team » crnl waking team 11 gormand frdric ph hosp crnl waking team » crnl waking team 12 grandjean estelle agtu univ crnl waking team » crnl waking team 13 guidon grard ai inserm crnl waking team » crnl waking team 14 guyon aurore crnl waking team » crnl waking team 15 inocente clara these hosp crnl waking team » crnl waking team 16 kocher laurence mcu ph hosp crnl waking team » crnl waking team 17 lin jian sheng dr1 inserm crnl waking team (team leader) crnl waking team » crnl waking team (team leader) 18 marinesco stphane cr1 inserm crnl waking team » crnl waking team 19 maucler caroline mast2 crnl waking team » crnl waking team 20 neuzeret pierre charles pdoc crnl waking team » crnl waking team 21 onen saban hakki ph hosp crnl waking team » crnl waking team 22 perier magali ai inserm crnl waking team » crnl waking team 23 raoux aude these hosp-univ crnl waking team » crnl waking team 24 sakai kazuya dr2 inserm crnl waking team » crnl waking team 25 seugnet laurent cr1 inserm crnl waking team » crnl waking team 26 spiegel karine cr1 inserm crnl waking team » crnl waking team 27 spruyt karen cr1 inserm crnl waking team » crnl waking team 28 vasylieva natalia these inserm crnl waking team » crnl waking team [ afficher les anciens membres ] dernire modification le lundi 15 mai 2017 13:54:45.
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