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accueil (home) crnl revues lectroniques site sommeil ralisation team leader : jian sheng lin - +33 (0)0478777116 equipe physiologie intégrée du système d'éveil, faculté de médecine, université claude bernard lyon 1, 8 avenue rockefeller, 69373 lyon cedex 08, france phone : +33 (0)478777041 - fax : +33 (0)478777150 email : u628@univ-lyon1.fr http://icoprem.univ-lyon1.fr/4-laboratoire41-crnl-physiologie-integree-du-systeme-d_eveil-ex-u628.html http://sommeil.univ-lyon1.fr http://crnl.univ-lyon1.fr/index.php/fr our goal is to unravel the mechanisms of wake and associated pathologies: narcolepsy, excessive daytime sleepiness, insomnia, metabolic disorders, sudden infant death syndrome. from a basic research standpoint, we dissect the mechanisms of wake through the study of the specific, complementary and synergistic roles of histaminergic and orexinergic neurons in particular. using specific knock out mice and detailed behavioral and electroencephalographic measures, we will determine how the two systems interact synergistically and integrate into the central mechanisms of sleep-wake alteration (js lin, k sakai). we also use intracellular recordings, local field potentials and biosensors to study the properties of the cortical network during different types of behavioral states, the respective role of diffuse ascending systems and specific cerebral nuclei, and the mechanisms and effects of extra-synaptic variations of neurotransmitter (s. crochet, s marinesco). from a physio-pathological and translational research standpoint, we work on 1) developing therapeutic approaches for narcolepsy and excessive daytime sleepiness using our knowledge of histaminergic and orexinergic systems (p franco, js lin), 2) investigating the interactions between sleep loss and metabolic disorders in lean subjects and obese patients and in animal models combining sleep/wake and metabolic alterations (k. spiegel), and 3) identifying new signaling pathways and biomarkers associated with wake thanks to drosophila molecular genetics (l. seugnet). our work is thus characterized by the use multidisciplinary methodological approaches: electrophysiology and behavior, biosensors, clinical investigations, molecular genetics, and the development of tools for both diagnostic and therapy. please click on individual names in the list below for more information. methodology electrophysiology (eeg, local field potential, intra and extracellular recordings in behavioral mice and cats) polysomnography in animals (mouse, cat) and humans (adult,child) biosensors (electrochemistry) immunohistochemistry neuro-behavioural testing neuropharmacology cognitive, metabolic and endocrine testing in humans animal models for sleep disorders (mouse, cat) sleep molecular genetics in drosophila keywords : waking, arousal, sleep, slow wave sleep, rem sleep, cortical activation, posterior hypothalamus, histamine, orexin, sleep-wake disorder, somnolence, waking substance, mesopontine tegmentum, neurophysiology, cat, mouse brief history of the laboratory scientific presentation of the laboratory (pdf) list of publication prsentation scientifique grand public (franais) bref historique du laboratoire (franais) group pictures les 29 membres # name position org. teams pubmed 1 lin jian sheng dr1 inserm crnl waking team (team leader) crnl waking team » crnl waking team (team leader) 2 perrot franoise sarcn inserm crnl waking team (secretary) # name position org. teams pubmed 1 achaintre laetitia inserm crnl waking team » crnl waking team 2 akaoka hideo cr1 cnrs crnl waking team » crnl waking team 3 anaclet christelle inserm crnl waking team » crnl waking team 4 buda colette ie inserm crnl waking team » crnl waking team 5 cespuglio raymond dr1 + hdr inserm crnl waking team » crnl waking team 6 challamel marie josephe cr1 inserm crnl waking team » crnl waking team 7 crochet sylvain cr1 inserm crnl waking team » crnl waking team 8 fernandez laura these inserm crnl waking team » crnl waking team 9 franco patricia mcuph hosp-univ crnl waking team » crnl waking team 10 gentet luc cr1 inserm crnl waking team » crnl waking team 11 gormand frdric ph hosp crnl waking team » crnl waking team 12 grandjean estelle agtu univ crnl waking team » crnl waking team 13 guidon grard ai inserm crnl waking team » crnl waking team 14 guyon aurore crnl waking team » crnl waking team 15 inocente clara these hosp crnl waking team » crnl waking team 16 kocher laurence mcu ph hosp crnl waking team » crnl waking team 17 lin jian sheng dr1 inserm crnl waking team (team leader) crnl waking team » crnl waking team (team leader) 18 marinesco stphane cr1 inserm crnl waking team » crnl waking team 19 maucler caroline mast2 crnl waking team » crnl waking team 20 neuzeret pierre charles pdoc crnl waking team » crnl waking team 21 onen saban hakki ph hosp crnl waking team » crnl waking team 22 perier magali ai inserm crnl waking team » crnl waking team 23 raoux aude these hosp-univ crnl waking team » crnl waking team 24 sakai kazuya dr2 inserm crnl waking team » crnl waking team 25 seugnet laurent cr1 inserm crnl waking team » crnl waking team 26 spiegel karine cr1 inserm crnl waking team » crnl waking team 27 spruyt karen cr1 inserm crnl waking team » crnl waking team 28 vasylieva natalia these inserm crnl waking team » crnl waking team [ afficher les anciens membres ] dernire modification le lundi 15 mai 2017 13:54:45.

Informations Whois

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%% [2600:3c03:0000:0000:f03c:91ff:feae:779d REQUEST] >> univ-lyon1.fr
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domain: univ-lyon1.fr
status: ACTIVE
hold: NO
holder-c: ULUC4-FRNIC
admin-c: GR258-FRNIC
tech-c: GR1378-FRNIC
zone-c: NFC1-FRNIC
nsl-id: NSL5813-FRNIC
registrar: GIP RENATER
Expiry Date: 2019-12-31T23:00:00Z
created: 1994-12-31T23:00:00Z
last-update: 2018-12-31T23:34:08Z
source: FRNIC

ns-list: NSL5813-FRNIC
nserver: dns.univ-lyon1.fr [134.214.100.6]
nserver: dns2.univ-lyon1.fr [134.214.100.245]
nserver: ccpntc3.in2p3.fr
nserver: ccpnvx.in2p3.fr
source: FRNIC

registrar: GIP RENATER
type: Isp Option 1
address: 23-25 Rue Daviel
address: 75013 PARIS
country: FR
phone: +33 1 53 94 20 30
fax-no: +33 1 53 94 20 31
e-mail: domaine@renater.fr
website: http://www.renater.fr
anonymous: NO
registered: 1998-01-01T12:00:00Z
source: FRNIC

nic-hdl: ULUC4-FRNIC
type: ORGANIZATION
contact: UNIVERSITE LYON 1 CLAUDE BERNARD
address: batiment 101, 27 A 43 boulevard du 11 Novembre 1918
address: 69622 Villeurbanne
country: FR
phone: +33 4 72 44 83 60
fax-no: +33 4 72 44 84 10
e-mail: gilles.rech@univ-lyon1.fr
registrar: GIP RENATER
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anonymous: NO
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nic-hdl: GR258-FRNIC
type: PERSON
contact: Gilles Rech
address: Universite de Lyon 1 - CISR
address: 43, boulevard du 11 Novembre 1918
address: 69622 Villeurbanne Cedex
country: FR
phone: +33 4 72 44 79 99
fax-no: +33 4 72 44 84 10
e-mail: gilles.rech@univ-lyon1.fr
registrar: GIP RENATER
changed: 2008-07-28T08:36:11Z domaine@renater.fr
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e-mail: rensvp@renater.fr
trouble: Information: http://www.Renater.fr/
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anonymous: NO
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  REFERRER http://www.nic.fr

  REGISTRAR AFNIC

SERVERS

  SERVER fr.whois-servers.net

  ARGS univ-lyon1.fr

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RegrInfo
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% Use '-h' option to obtain more information about this service.
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% [2600:3c03:0000:0000:f03c:91ff:feae:779d REQUEST] >> univ-lyon1.fr
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  REGISTERED yes

ADMIN

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  CONTACT Gilles Rech

ADDRESS
Universite de Lyon 1 - CISR
43, boulevard du 11 Novembre 1918
69622 Villeurbanne Cedex

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TECH

  HANDLE GR1378-FRNIC

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  CONTACT GIP RENATER

ADDRESS
GIP RENATER
Ensam
151, boulevard de l'Hopital
75013 Paris

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  PHONE +33 1 53 94 20 30

  FAX +33 1 53 94 20 31

  EMAIL rensvp@renater.fr

TROUBLE
Information: http://www.Renater.fr/
abuse reports, ... mailto:CertSVP@Renater.fr
questions: mailto:RenSVP@Renater.Fr

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TECH-C
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OWNER

  HANDLE ULUC4-FRNIC

  TYPE ORGANIZATION

  CONTACT UNIVERSITE LYON 1 CLAUDE BERNARD

ADDRESS
batiment 101, 27 A 43 boulevard du 11 Novembre 1918
69622 Villeurbanne

  COUNTRY FR

  PHONE +33 4 72 44 83 60

  FAX +33 4 72 44 84 10

  EMAIL gilles.rech@univ-lyon1.fr

  SPONSOR GIP RENATER

  CHANGED 2009-12-02

  ANONYMOUS NO

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  ELIGSTATUS ok

  ELIGDATE 2005-06-22T22:00:00Z

  REACHSTATUS not identified

  SOURCE FRNIC

DOMAIN

  STATUS ACTIVE

  HOLD NO

  SPONSOR GIP RENATER

  EXPIRY DATE 2019-12-31T23:00:00Z

  CREATED 1994-12-31

  CHANGED 2018-12-31

  SOURCE FRNIC

  HANDLE NSL5813-FRNIC

NSERVER

  DNS.UNIV-LYON1.FR 134.214.100.6

  DNS2.UNIV-LYON1.FR 134.214.100.245

  CCPNTC3.IN2P3.FR 134.158.69.191

  CCPNVX.IN2P3.FR 134.158.69.104

  NAME univ-lyon1.fr

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